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Nanomilling From Screening to Scale Up
A client came to Altasciences’ CDMO with a highly active compound which was headed towards clinical trials based on excellent in vitro activity and a good toxicity profile. However, due to very poor aqueous solubility and less than desirable bioavailability, improvements to the formulation were required to realize all the benefits of the drug’s inherent activity.
In this case study, we investigate the suitability of nanomilling for the client’s drug to develop a stable, nanoparticulate suspension formulation of the active pharmaceutical ingredient (API) that would improve bioavailability.
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